About Probiotics and Good Gut Health they work

5 Claims About Probiotics and Good Gut Health
i have personally used many products, after discovering i had gi problems. I went to a group specializing in these issues, chaired by a medical doctor that had had disease.  it changed my life. i have had many clients of mind-body medicine that have taken over-the-counter probiotics and have seen massage changes in their physical mental and spiritual presentations. i use many products and consult within the area. If you health is important. Heed these pages

How to Invest: 8 Steps Euros format

How to Invest: 8 Steps (with Pictures) - wikiHow

the main thing is to write out a plan with strategy and tactics. "no one plans to fails; those who fail; fail to plan"

BRAIN SCIENCE and neurological blood flow

http://redwood.berkeley.edu/seminar-info.php?id=188
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Aniruddha Das
Columbia University
What Hemodynamics can and cannot tell us about neural activity in the brain
Tuesday 24th of January 2012 at 12:00pm
560 Evans Hall
Brain imaging is based on measuring not neural activity but rather, brain hemodynamics – local changes in blood volume, blood flow and oxygenation. These hemodynamic signals are understood to reliably report local neural activity. In particular, it is typically assumed that the hemodynamics follow uniformly from local neural responses, with increases in neural activity causing local deoxygenation in the blood which then drives fresh oxygenated blood into the activated regions of the brain. However, the neurophysiology of brain imaging has primarily been studied in anesthetized animals. Neural and hemodynamic responses have rarely been compared in alert subjects to understand how these signals relate to each other in individuals engaged in a behavioral task. By recording with electrodes while simultaneously imaging hemodynamic signals in alert behaving monkeys, we find a complex relationship between hemodynamics and neural activity. This complexity is evident at two levels. First we find that when the animals are engaged in a systematic visual task, the hemodynamic signal recorded from their primary visual cortex (V1) contains a strong task-related component in addition to visually evoked responses. This task-related component is a novel anticipatory signal that dilates local arteries and brings in fresh blood ahead of an expected visual trial. Unlike the visually driven signal, this task-related component is independent of visual input or measurable local neural activity, whether spiking or local field potential (LFP). We speculate that this task-related signal may result from distal neuromodulatory inputs into visual cortex. Next, we find that even the visually evoked hemodynamic signal is not driven by deoxygenation in the blood per se. Rather, it is likely driven by a process that occurs in parallel, roughly anticipating the local demand before it leads to any blood deoxygenation. These findings should lead to a better appreciation both of the multiple neural mechanisms underlying brain hemodynamics and the causal relationships linking neural activity and blood flow.

Star Trek TNG Ambient Engine Noise

Sooooo Soothing: Star Trek TNG Ambient Engine Noise

Osho - No Society Wants You To Become Wise - YouTube

Osho - No Society Wants You To Become Wise - YouTube

ATP is ??? & its relations to NO levels autoimmune systems/immunizations

http://ajpregu.physiology.org/cgi/content/full/289/3/R738
I suspect that stress acts as an adjuvant by decreasing NO levels. When the immune system is turned on there is what is called the “respiratory burst”, which is the production of superoxide by immune cells. This superoxide pulls down the local NO level and that lower NO level modulates the activity of the lysosome by inhibiting the V-ATPase which acidifies the lysosome and regulates the digestion of cellular contents via autophagy. Under conditions of oxidative stress, autophagy proceeds more slowly and incompletely resulting in more incompletely digested components which are expelled from the cell.
The silver deposits of argyria occur because the silver is reduced to metallic silver in the reducing conditions of the lysosome and is then expelled into the extravascular space where it is permanent. Stuff that is incompletely digested gets expelled too, but then the dendritic cells finish the job (they can’t with silver).
I think this is the generic mechanism for autoimmune sensitization. Low NO, or oxidative stress (they are the same thing) interferes with autophagy via inhibition of the V-ATPase and undigested cellular bits are expelled into the extravascular space. Dendritic cells pick up those bits of incompletely digested cellular contents and (if the local NO level is low), process them with MHC I resulting in autoimmune sensitization. I think this is how the immune sensitization associated with things like primary biliary cirrhosis, stiff person syndrome, and probably MS too.
I say that low NO “interferes”, but actually it is a regulated response. Low NO is one of the signals that indicate a metabolic crisis, where ATP needs to be conserved. Turning off autophagy during an ATP crisis is good ATP crisis management. If you are “running from a bear”, you don’t need to worry about antigens.
Some amount of this autoimmune sensitization might be a feature. When a tumor is growing out of control, it will be metabolically stressed and may expel debris that the immune system picks up on and ultimately attacks. If that site is small and local it may be cleared and resolved. Similarly if you have a parasite or an infection there will be lots of local inflammation which causes metabolic stress and shifts the local dendritic cells more to a non-self bias. I think the problem with autoimmune sensitization is due to low NO causing local metabolic stress which eventually causes autoimmune sensitization.
That might be a generic way to removed damaged cells. If a cell can’t generate enough ATP to sustain itself it will eventually exhibit defective autophagy and oxidative stress due to not enough mitochondria (a consequence of low NO and defective autophagy). If a cell can’t sustain itself it needs to be gotten rid of.
# Sastraon 18 Feb 2008 at 7:46 pm

BPS Research Digest: Effect of anger on negotiations depends on cultural context

BPS Research Digest: Effect of anger on negotiations depends on cultural context