Monday, November 7, 2011
Monday, May 9, 2011
ATP is ??? & its relations to NO levels autoimmune systems/immunizations
http://ajpregu.physiology.org/cgi/content/full/289/3/R738
I suspect that stress acts as an adjuvant by decreasing NO levels. When the immune system is turned on there is what is called the “respiratory burst”, which is the production of superoxide by immune cells. This superoxide pulls down the local NO level and that lower NO level modulates the activity of the lysosome by inhibiting the V-ATPase which acidifies the lysosome and regulates the digestion of cellular contents via autophagy. Under conditions of oxidative stress, autophagy proceeds more slowly and incompletely resulting in more incompletely digested components which are expelled from the cell.
The silver deposits of argyria occur because the silver is reduced to metallic silver in the reducing conditions of the lysosome and is then expelled into the extravascular space where it is permanent. Stuff that is incompletely digested gets expelled too, but then the dendritic cells finish the job (they can’t with silver).
I think this is the generic mechanism for autoimmune sensitization. Low NO, or oxidative stress (they are the same thing) interferes with autophagy via inhibition of the V-ATPase and undigested cellular bits are expelled into the extravascular space. Dendritic cells pick up those bits of incompletely digested cellular contents and (if the local NO level is low), process them with MHC I resulting in autoimmune sensitization. I think this is how the immune sensitization associated with things like primary biliary cirrhosis, stiff person syndrome, and probably MS too.
I say that low NO “interferes”, but actually it is a regulated response. Low NO is one of the signals that indicate a metabolic crisis, where ATP needs to be conserved. Turning off autophagy during an ATP crisis is good ATP crisis management. If you are “running from a bear”, you don’t need to worry about antigens.
Some amount of this autoimmune sensitization might be a feature. When a tumor is growing out of control, it will be metabolically stressed and may expel debris that the immune system picks up on and ultimately attacks. If that site is small and local it may be cleared and resolved. Similarly if you have a parasite or an infection there will be lots of local inflammation which causes metabolic stress and shifts the local dendritic cells more to a non-self bias. I think the problem with autoimmune sensitization is due to low NO causing local metabolic stress which eventually causes autoimmune sensitization.
That might be a generic way to removed damaged cells. If a cell can’t generate enough ATP to sustain itself it will eventually exhibit defective autophagy and oxidative stress due to not enough mitochondria (a consequence of low NO and defective autophagy). If a cell can’t sustain itself it needs to be gotten rid of.
# Sastraon 18 Feb 2008 at 7:46 pm
Saturday, July 10, 2010
Wednesday, May 12, 2010
Tuesday, May 11, 2010
Sunday, November 29, 2009
How unusual: Plastics & chem affects childs neurons
Phthalates, Common Plastics Chemicals, Linked To ADHD Symptoms. Mother nature is spitting the junk back into our brains
Tuesday, September 1, 2009
touch the sky Its all in your mind
touchthis: "'If you play it safe you stagnate is this league. Maybe we'll bust, but if we hit it, we'll hit it big.' - Jimmy Johnson, coach of the Miami Dolphins"
Monday, August 10, 2009
Thursday, August 6, 2009
Warm Mineral springs=sacred healing lake, FLorida
"“The following letter was placed in the mail box of a friend of mine here in WMS (Warm Mineral Springs.) I thought you and your group might like to keep informed since you have had an ongoing interest I am told. The same friend told me that the new ownership is going to begin to dump a chemical called “alum” in the Springs. I don’t know what this chemical is, but I am concerned. Here is what the letter says:
Warm Mineral Springs, long known for its healing waters and as underwater burial caves of ancient
Amer-Indian tribes is now the site of a modern tragedy. Unlike western materialists, indigenous peoples recognized the Tree People as relatives, whose job is to connect the earth to sky, and the firmament to heaven. The extended canopy of Melaleuca Eucalyptus trees, formerly located on the west bank of the springs were known for their lovely screening ambiance, and delicate fragrance which frequently traveled upon the wind and over the waters. These trees, who patiently sheltered Warm Mineral Springs for over fifty years, were murdered on August 3rd and 4th, 2009 by the Cypress Lending Group, the current owners of the mineral springs. It is rumored that the Cypress Group is afraid of lawsuits lest a tree fall upon one of their human customers. It is further “reasoned” that Melaleuca trees are not indigenous to Florida and do not belong to the naturescape. Many residents, however, have recognized the contributions of the trees, despite their immigrant status. Ironically, Melaleuka leaves are highly regarded the world over for their healing properties and are the source of Tea Tree oil. The Melaleucas will be deeply missed by all people of heart who hold respect for the beauty of nature. The following poem, “Trees”, written by Jo yce Kilmer, is offered in Memoriam as a gesture of comfort for the Warm Mineral Springs residents who mourn.”
Trees
I think that I shall never see
A poem as lovely as a tree.
A tree whose hungry mouth is prest
Against the sweet earths flowing breast;
A tree that looks at God all day,
And lifts her leafy arms to pray.
A tree that may in summer wear
A nest of robins in her hair;
Upon whose bosom snow has lain’
Who intimately lives with rain.
Poems were made by fools like me,
But only God can make a tree."
Warm Mineral Springs, long known for its healing waters and as underwater burial caves of ancient
Amer-Indian tribes is now the site of a modern tragedy. Unlike western materialists, indigenous peoples recognized the Tree People as relatives, whose job is to connect the earth to sky, and the firmament to heaven. The extended canopy of Melaleuca Eucalyptus trees, formerly located on the west bank of the springs were known for their lovely screening ambiance, and delicate fragrance which frequently traveled upon the wind and over the waters. These trees, who patiently sheltered Warm Mineral Springs for over fifty years, were murdered on August 3rd and 4th, 2009 by the Cypress Lending Group, the current owners of the mineral springs. It is rumored that the Cypress Group is afraid of lawsuits lest a tree fall upon one of their human customers. It is further “reasoned” that Melaleuca trees are not indigenous to Florida and do not belong to the naturescape. Many residents, however, have recognized the contributions of the trees, despite their immigrant status. Ironically, Melaleuka leaves are highly regarded the world over for their healing properties and are the source of Tea Tree oil. The Melaleucas will be deeply missed by all people of heart who hold respect for the beauty of nature. The following poem, “Trees”, written by Jo yce Kilmer, is offered in Memoriam as a gesture of comfort for the Warm Mineral Springs residents who mourn.”
Trees
I think that I shall never see
A poem as lovely as a tree.
A tree whose hungry mouth is prest
Against the sweet earths flowing breast;
A tree that looks at God all day,
And lifts her leafy arms to pray.
A tree that may in summer wear
A nest of robins in her hair;
Upon whose bosom snow has lain’
Who intimately lives with rain.
Poems were made by fools like me,
But only God can make a tree."
ancient wisdom
"'Who takes Heaven as his ancestor, Virtue as his home,
the Tao as his door, and who becomes change -- is a
Sage.' -- Chuang Tzu, Inner Chapters
'The Tao is very close, but everyone looks far away.
Life is very simple, but everyone seeks difficulty.'
-- Taoist Sage, 200 B.C"
the Tao as his door, and who becomes change -- is a
Sage.' -- Chuang Tzu, Inner Chapters
'The Tao is very close, but everyone looks far away.
Life is very simple, but everyone seeks difficulty.'
-- Taoist Sage, 200 B.C"
Friday, July 24, 2009
Thursday, July 16, 2009
CANCER:DACH1 a Key Protein for Tumor Suppression in ER+ Breast Cancer
Newswise Medical News | DACH1 a Key Protein for Tumor Suppression in ER+ Breast Cancer
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GENETIC counseling is a great new filed for a start in medicine and it is a Masters. So if you want to reinvent yourself and really aid others and participate in the growing field of genetics; check our colleges to see if they offer the degree. WWW.usf.edu in Tampa, FL does.
\
GENETIC counseling is a great new filed for a start in medicine and it is a Masters. So if you want to reinvent yourself and really aid others and participate in the growing field of genetics; check our colleges to see if they offer the degree. WWW.usf.edu in Tampa, FL does.
Sunday, July 12, 2009
Unsafe Food Supply: How r U?
Newswise Breaking News Channel | Food Safety
The food in the U.S.A. is killing us and our animals. Digestive Enzymes seem to be an answer; but not a cure! Here is a survey of scientific articles on tracking down the microbes that are in our food. But, why, the most advanced country in the world in may ways, is our food supply so full of chemicals and fats and contaminants. You won't find out here; this is just sample reading list of experts--to date. Enjoy==
The food in the U.S.A. is killing us and our animals. Digestive Enzymes seem to be an answer; but not a cure! Here is a survey of scientific articles on tracking down the microbes that are in our food. But, why, the most advanced country in the world in may ways, is our food supply so full of chemicals and fats and contaminants. You won't find out here; this is just sample reading list of experts--to date. Enjoy==
Friday, July 10, 2009
Middle_Aged Women Read Sex Novels
Middle-aged women want to read about sex
Give British women a romance novel or a novel with a little raunchy sex and they're in heaven.
Wednesday, July 8, 2009
The poll of nearly 2,000 women between the ages of 45 and 60 found romantic fiction was the most popular reading fare, preferred by 35 percent of those surveyed, The Daily Telegraph reported Tuesday.
Steamy passages generated heat for nearly two-thirds of respondents, with more than half of the respondents calling sex in books "titillating," the survey conducted by Astral moisturizer.
On top of that, 10 percent more questioned about their reading habits said they actively chose books that featured lots of sex scenes.
"This research shows that reading for pleasure is still an incredibly popular pastime for women," Astral spokeswoman Trisha MacNair said. "However, I am surprised to see just how many women liked sex scenes in books, with most telling us that there was a strong titillation factor."
Crime and mystery novels received 33 percent of the vote, and "other" novels, 31 percent.
Not surprising, reference books were the least popular.
Monday, December 8, 2008
Quantum Physics: Finite Barrier Quantum Well, Britney Spears guide to Semiconductor Physics
By Jove, I knew Brittney Spears was smart, but a Quantum Physicist--I am waiting for the rap music, complete with sexy quantum foam, black holes and a singularity point.
She lectures now on the Quantum-Well, and as President Reagan used to say...."Welllllll...thats a deep subject.
Learn now what that Doctorate from Berkeley, UC
http://physics.about.com/od/quantumphysics/Quantum_Physics.htm
A little review for those who have forgotten abut Schroediner's Cat and quantum consciousness.
Britney lectures are too deep for most of us as the ' NATIONAL INTRUDER" has just uncovered,she has not one, not 2 but 3 Doctorates in Quantum Physics, (berklety/uc), cern.ch (switzerland, the first real internet site; which Al Gore, M.B.A. (harvard did not invent) and from the Cantubury College of Advanced Studies (Saraota, fl 34236--World arts and science of art capital) and Ball State U, in Muncie in (bsu.edu) in sub atomic particle neutrion theory). How can we mortals with our average Princeton, Yale and MIT degrees keep up. Read on.
And as her hair is growing back we find John Baez (joans's brother, I do not know, but I liked her music)...http://tinyurl.com/6xtwxk finds more fuel for the 10th dimension of space. Time, Time, what have you done to me (in only 2 dimensions)
Me: http://www.twitter.com/cantubury
http://www.eyeoftheraaven.blogspot.com
Sorry Brit is calling with some breaking alerts on the south Miami --Arts Basel art celebration with news on quantum art by David Gonya,
http://www.highstonestudios.com, and staceygoes.com
have to go: Qu U later. cantubury
By Jove, I knew Brittney Spears was smart, but a Quantum Physicist--I am waiting for the rap music, complete with sexy quantum foam, black holes and a singularity point.
She lectures now on the Quantum-Well, and as President Reagan used to say...."Welllllll...thats a deep subject.
Learn now what that Doctorate from Berkeley, UC
http://physics.about.com/od/quantumphysics/Quantum_Physics.htm
A little review for those who have forgotten abut Schroediner's Cat and quantum consciousness.
Britney lectures are too deep for most of us as the ' NATIONAL INTRUDER" has just uncovered,she has not one, not 2 but 3 Doctorates in Quantum Physics, (berklety/uc), cern.ch (switzerland, the first real internet site; which Al Gore, M.B.A. (harvard did not invent) and from the Cantubury College of Advanced Studies (Saraota, fl 34236--World arts and science of art capital) and Ball State U, in Muncie in (bsu.edu) in sub atomic particle neutrion theory). How can we mortals with our average Princeton, Yale and MIT degrees keep up. Read on.
And as her hair is growing back we find John Baez (joans's brother, I do not know, but I liked her music)...http://tinyurl.com/6xtwxk finds more fuel for the 10th dimension of space. Time, Time, what have you done to me (in only 2 dimensions)
Me: http://www.twitter.com/cantubury
http://www.eyeoftheraaven.blogspot.com
Sorry Brit is calling with some breaking alerts on the south Miami --Arts Basel art celebration with news on quantum art by David Gonya,
http://www.highstonestudios.com, and staceygoes.com
have to go: Qu U later. cantubury
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